Weekend in SF's Mission District

Set in an 1872 mansion, the 21-room property brims with authentic Victorian details—ornate woodwork; marble fireplaces; featherbeds—minus the chintz (not a weathered doily in sight). Don’t miss the rooftop deck with 360-degree views of the city.

Siblings Danielle and Luke Teller helm the well-edited Afterlife Boutique, which carries reconstructed antique jewelry by the shop's Adoura Demode line and collectible rock-concert T-shirts priced from $45 to $1,000.

The light-filled store is a treasure hunter's dream, filled with everything from Japanese paper goods to wool blankets made on Prince Edward Island.

The izakaya Nombe—its name translates, roughly, to “drunkard”—serves haute Japanese pub food (grilled shishito peppers with bottarga; grilled skewers of chicken thigh with ume and shiso) accompanied by a great sake list. Added bonus: the kitchen is open until 2 a.m. on Fridays and Saturdays, an anomaly in the city.

Chef-owner Matt Straus turns out simple, yet delicious, seasonal dishes at this intimate restaurant. But for a real treat, ask for the off-menu burger with Époisses cheese.

This showcase for local, cutting-edge artists relocated in fall 2009 to a soaring 4,000-square-foot gallery.